The borough is well located with good transport and infrastructure links to the rest of Lancashire, Greater Manchester and beyond. Blackburn and Darwen are both served by the Clitheroe to Rochdale rail line. Blackburn is also served by the York to Blackpool line and the Blackburn to Manchester Victoria Line. Regional rail use statistics show that in 2017/18 the main station in the borough was Blackburn with 1,258,190 entries and exits, ranking it 453rd in Great Britain.
The borough's road infrastructure allows good connectivity, with the A666 providing an access corridor to Bolton, Greater Manchester, Yorkshire and the Ribble Valley. The borough also hosts three motorway junctions of the M65 which provides quick access to Preston, Burnley and the rest of Lancashire, the M61, the M66 and the M6.